Nutrisorb Methyl B12 Vitamins · Biocare | 15 ml

Why we chose this

Most vitamin B12 supplements use a single form of the vitamin - usually cyanocobalamin (synthetic) or, in better-quality products, methylcobalamin alone. This formula is different. Biocare's Nutrisorb® Methyl B12 provides both active coenzyme forms of B12 - methylcobalamin and adenosylcobalamin - in a single liquid. These are the two forms in which vitamin B12 actually functions inside the body. Methylcobalamin is the form of B12 most concentrated in the brain and nervous tissue. Adenosylcobalamin (also called 5′-deoxyadenosylcobalamin) is the mitochondrial form of B12. This formula provides both - covering both the methylation-dependent and the mitochondrial pathways in which B12 is required. It is the simplest possible format for one of the most commonly deficient nutrients in Western diets.

• Normal energy-yielding metabolism Vitamin B12 contributes to normal energy-yielding metabolism.
• Normal function of the nervous system Vitamin B12 contributes to the normal function of the nervous system.
• Normal psychological function Vitamin B12 contributes to normal psychological function.
• Reduction of tiredness and fatigue Vitamin B12 contributes to the reduction of tiredness and fatigue.
• Normal red blood cell formation Vitamin B12 contributes to normal red blood cell formation.
• Normal function of the immune system Vitamin B12 contributes to the normal function of the immune system.
• Normal homocysteine metabolism Vitamin B12 contributes to normal homocysteine metabolism.
• Normal cell division Vitamin B12 contributes to the process of cell division.

 Who is this formula for?

• Vegans and vegetarians, for whom B12 is the single most critical nutrient to supplement — there is no reliable plant-based dietary source of vitamin B12.
• Adults over 50, in whom stomach acid production — required to separate B12 from food proteins — often declines, reducing dietary B12 absorption.
• People with low stomach acid (hypochlorhydria), atrophic gastritis or who take proton pump inhibitors (PPIs) or H2 blockers long-term, as these conditions significantly impair B12 absorption from food.
• Those who have been told they have low or borderline serum B12 levels and want a high-potency liquid supplement with both active coenzyme forms.
• Anyone who prefers a liquid format over capsules or tablets, including people with swallowing difficulties or digestive sensitivities.

Frequently asked questions

What is the difference between methylcobalamin and adenosylcobalamin? Both are active coenzyme forms of vitamin B12 — the forms in which B12 actually functions inside cells. Methylcobalamin operates primarily in the cytoplasm: it is the coenzyme for methionine synthase, the enzyme responsible for converting homocysteine to methionine and for regenerating active folate. Adenosylcobalamin operates primarily inside mitochondria: it is the coenzyme for methylmalonyl-CoA mutase, which is involved in fatty acid and amino acid metabolism and energy production via the citric acid cycle. Both pathways require adequate B12. Most supplements provide only one form; this formula provides both.

Why is the dose so high at 500 µg (20,000% NRV)? Vitamin B12 is absorbed by two separate mechanisms. The primary route — intrinsic factor-mediated absorption — is saturable at relatively low doses (around 1–2 µg per meal). At higher doses, a second passive absorption route operates, absorbing approximately 1% of the dose regardless of intrinsic factor. At 500 µg, passive absorption accounts for roughly 5 µg — a meaningful contribution to daily needs, even in people with compromised intrinsic factor production. B12 is water-soluble and excess is excreted in urine; EFSA has not established a tolerable upper intake level for B12.

Why are vegans particularly at risk of B12 deficiency? Vitamin B12 is produced exclusively by microorganisms and is found in the diet almost entirely through animal products — meat, fish, dairy, eggs and (in small amounts) fermented foods. Plant foods do not contain meaningful amounts of B12. Some algae such as spirulina contain B12 analogues that are not biologically active in humans and may even interfere with true B12 metabolism.

Who else is at elevated risk of B12 deficiency? Beyond vegans and vegetarians, B12 deficiency is more common in adults over 50 (due to declining stomach acid production), people with atrophic gastritis, those taking proton pump inhibitors or H2 blockers long-term, people who have had gastric bypass surgery, and those with conditions affecting the terminal ileum (where B12 is absorbed).

Can I take this under the tongue instead of swallowing it in water? Yes. Sublingual administration — placing the drops directly under the tongue and holding briefly before swallowing — allows the active ingredients to be partially absorbed through the mucous membrane directly into circulation, bypassing the digestive tract. You can also simply add the drops to a glass of water and take with a meal.

How long does one bottle last? At the recommended dose of 6 drops per day, one 15 ml bottle provides approximately 43 servings — around six weeks of daily use.

Does this product need to be refrigerated? No refrigeration is required. Store in a cool, dry place away from direct sunlight, with the cap sealed between uses.